Detalhe da pesquisa
1.
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
N Engl J Med
; 382(24): 2289-2301, 2020 06 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32521132
2.
Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria.
N Engl J Med
; 380(6): 549-558, 2019 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30726693
3.
EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks.
Hepatology
; 71(5): 1546-1558, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31512765
4.
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
N Engl J Med
; 376(1): 41-51, 2017 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27959715
5.
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin.
Mol Genet Metab
; 131(4): 418-423, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33199206
6.
Uranus's northern polar cap in 2014.
Geophys Res Lett
; 45(11): 5329-5335, 2018 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32546873
7.
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.
Lancet
; 383(9911): 60-68, 2014 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24094767
8.
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
N Engl J Med
; 376(18): e38, 2017 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28467871
9.
GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.
Proc Natl Acad Sci U S A
; 106(11): 4372-7, 2009 Mar 17.
Artigo
Inglês
| MEDLINE | ID: mdl-19246396
10.
Patient Perspective on Acute Hepatic Porphyria with Sporadic Attacks: A Chronic Disease with Substantial Health-Related Quality of Life Impacts.
Adv Ther
; 39(9): 4330-4345, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35907153
11.
Normal reference ranges for urinary δ-aminolevulinic acid and porphobilinogen levels.
JIMD Rep
; 57(1): 85-93, 2021 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-33473344
12.
A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver.
Clin Pharmacol Ther
; 110(5): 1250-1260, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34510420
13.
Retraction for Zhong et al. GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.
Proc Natl Acad Sci U S A
; 109(13): 5134, 2012 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22411792
14.
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria.
Clin Pharmacol Ther
; 108(1): 63-72, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31994716
15.
Widespread carbon-bearing materials on near-Earth asteroid (101955) Bennu.
Science
; 370(6517)2020 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33033153
16.
A Survey of Small-Scale Waves and Wave-Like Phenomena in Jupiter's Atmosphere Detected by JunoCam.
J Geophys Res Planets
; 125(7): e2019JE006369, 2020 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-32728504
17.
Clinical Pharmacists Improve Patient Outcomes and Expand Access to Care.
Fed Pract
; 36(10): 471-475, 2019 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-31768098
18.
Patient Perspective on Acute Intermittent Porphyria with Frequent Attacks: A Disease with Intermittent and Chronic Manifestations.
Patient
; 11(5): 527-537, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29915990
19.
A New, Long-Lived, Jupiter Mesoscale Wave Observed at Visible Wavelengths.
Astron J
; 156(2)2018 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-30510304
20.
NEPTUNE'S DYNAMIC ATMOSPHERE FROM KEPLER K2 OBSERVATIONS: IMPLICATIONS FOR BROWN DWARF LIGHT CURVE ANALYSES.
Astrophys J
; 817(2)2016 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28127087